![]() Compared with trkA and trkC knockouts, the proportion of CR-positive neurons in mandibular and maxillary regions of the trigeminal ganglion of trkB knockout mice is decreased. Only free nerve endings were observed in tissue of trkB knockout mice. However, Ruffini endings were not present in the periodontal ligament of trkB knockout mice. PGP 9.5-positive fibers in the incisal periodontal ligaments of trkA and trkC knockout mice form Ruffini endings distinguished by dendritic ramifications and branches. Innervation patterns of PGP 9.5- and CGRP-immunoreactive fibers were examined in the periodontal ligament of the knockout mice. ![]() N2 - To clarify the role of neurotrophin receptors in the development of Ruffini endings, periodontal ligaments and trigeminal ganglia of trkA, trkB, and trkC knockout mice were immunostained for protein gene product 9.5 (PGP 9.5), calcitonin gene-related peptide (CGRP), parvalbumin (PV), and calretinin (CR). T1 - Ruffini endings are absent from the periodontal ligament of trkB knockout mice These findings indicate that the development of periodontal Ruffini endings is regulated by trkB-dependent and CR-coexpressing neurons.", These findings indicate that the development of periodontal Ruffini endings is regulated by trkB-dependent and CR-coexpressing neurons.Ībstract = "To clarify the role of neurotrophin receptors in the development of Ruffini endings, periodontal ligaments and trigeminal ganglia of trkA, trkB, and trkC knockout mice were immunostained for protein gene product 9.5 (PGP 9.5), calcitonin gene-related peptide (CGRP), parvalbumin (PV), and calretinin (CR). Most of the Ruffini corpuscles are located deep in the skin and also near joints, responding to mechanical changes and deformations within the joint capsules.To clarify the role of neurotrophin receptors in the development of Ruffini endings, periodontal ligaments and trigeminal ganglia of trkA, trkB, and trkC knockout mice were immunostained for protein gene product 9.5 (PGP 9.5), calcitonin gene-related peptide (CGRP), parvalbumin (PV), and calretinin (CR). This type of nerve ending responds to stretch and is important in changes in finger position and movement allowing alterations in grip. ![]() Ruffini corpuscles- spindle shaped nerve endings located in dermis and subcutaneous tissue of the skin. These discs are located in hair follicles therefore, they would not be expected on the sole of the foot, which does not contain hair.ĥ. ![]() Merkel discs-Not encapsulated, but are cup-shaped and function in determining light and crude touch, such as feeling the texture of an object. Respond to changes in pressure, coarse touch, vibration, and increased tension.Ĥ. Pacinian Corpuscles - located in deeper layer of skin, deeper than Meissner. This type of mechanoreceptor is found in abundance within the dermis of hairless skinģ. Meissner corpuscles-light, discriminatory touch detected by the palms and digits of the hands and the soles of the feet are provided by small encapsulated nerve endings knwon as Meissner corpuscles. Free nerve endings-are the most common type of nerve endings, they are of various types and respond to various stimuli, but are most commonly associated with temperature and pain.Ģ. ![]()
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